# Peter Attia's High-Leucine Protein Distribution Protocol - Clinical Longevity Review & Consensus Audit

> **Consensus Verdict**: Leucine trigger and protein distribution for muscle protein synthesis in adults (Morton RW, et al., Br J Sports Med 2018; Phillips SM, et al., Sports Med 2014).

## 1. Executive Summary & Scores
- **Longevity Evidence Score**: **92/100**
- **Evidence Quality Tier**: **silver**
- **Human Clinical Evidence Strength**: 94/100
- **Primary Longevity Classification**: nutrition
- **Safety Margin Score**: 84/100 (Higher is safer)
- **Time Burden**: ~15 minutes/day
- **Estimated Monthly Cost**: inexpensive
- **Adherence Friction**: 3/10 (Lower is easier to sustain)

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## 2. Biological Mechanisms of Action
Leucine acts as a nutrient sensor that activates Sestrin2, releasing GATOR2 to trigger mTORC1 assembly at the lysosomal membrane, driving ribosomal translation of structural muscle proteins.

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## 3. Canonical Longevity Vector Impacts (The 8 Longevity Pillars)

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## 4. Practical Protocol & Administration Guidelines
- **Standard Clinical Dosage**: 1.6-2.2g/kg total protein (30-50g protein per meal)
- **Recommended Timing**: Distributed across meals (Breakfast, Lunch, Dinner)
- **Administration Type**: nutrition
- **Recommended Biomarkers to Monitor**: strength, satiety, soreness, energy, digestive_comfort

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## 5. Safety, Contraindications & Drug Interactions
- **Contraindications**: None reported in standard human trials with recommended doses.
- **Safety Profile**: safe - Ensure adequate water intake. Individuals with pre-existing stage 4-5 chronic kidney disease should consult their nephrologist.

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## 6. Peer-Reviewed Human Clinical Trials & Key PMIDs
1. **The role of protein in weight loss and maintenance** [PMID: 25926512]
   - Link: https://pubmed.ncbi.nlm.nih.gov/25926512/
2. **A systematic review, meta-analysis and meta-regression of the effect of protein supplementation on resistance training-induced gains in muscle mass and strength in healthy adults** [PMID: 28698222]
   - Link: https://pubmed.ncbi.nlm.nih.gov/28698222/

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## 7. Canonical Citation & Web Verification
- **Official Web Review**: [Peter Attia's High-Leucine Protein Distribution Protocol on LongevityReviews](https://longevityreviews.org/modalities/attia_protein_distribution)
- **Last Evidence Calibration**: 2026-08-08
- **Review Policy**: 0% sponsored placements, independent peer-reviewed consensus.