# Phosphatidylserine - Clinical Longevity Review & Consensus Audit

> **Consensus Verdict**: Enhance your focus and blunt your response to stress today by supplying the essential building block for your brain cell membranes. Phosphatidylserine supports the cellular communication required for both immediate cognitive performance and long-term neuronal health.

## 1. Executive Summary & Scores
- **Longevity Evidence Score**: **89/100**
- **Evidence Quality Tier**: **silver**
- **Human Clinical Evidence Strength**: 82/100
- **Primary Longevity Classification**: supplements
- **Safety Margin Score**: 92/100 (Higher is safer)
- **Time Burden**: ~15 minutes/day
- **Estimated Monthly Cost**: inexpensive
- **Adherence Friction**: 3/10 (Lower is easier to sustain)

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## 2. Biological Mechanisms of Action
Integrates into neuronal cell membranes, enhancing receptor fluidity and signaling; dampens ACTH release from the pituitary gland.

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## 3. Canonical Longevity Vector Impacts (The 8 Longevity Pillars)

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## 4. Practical Protocol & Administration Guidelines
- **Standard Clinical Dosage**: 300-600mg
- **Recommended Timing**: Post-workout or Evening
- **Administration Type**: supplement
- **Recommended Biomarkers to Monitor**: soreness, brain_longevity, focus, memory, stress, calmness

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## 5. Safety, Contraindications & Drug Interactions
- **Contraindications**: None reported in standard human trials with recommended doses.
- **Safety Profile**: low_risk - Well tolerated within physiological ranges.

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## 6. Peer-Reviewed Human Clinical Trials & Key PMIDs
1. **Soybean-derived phoshatidylserine improves memory function of the elderly Japanese subjects with memory complaints.** [PMID: 20523044]
   - Link: https://pubmed.ncbi.nlm.nih.gov/20523044/
2. **Effects of phosphatidylserine in age-associated memory impairment.** [PMID: 2058345]
   - Link: https://pubmed.ncbi.nlm.nih.gov/2058345/
3. **Blunting by chronic phosphatidylserine administration of the stress-induced activation of the hypothalamo-pituitary-adrenal axis in healthy men.** [PMID: 1328421]
   - Link: https://pubmed.ncbi.nlm.nih.gov/1328421/
4. **Effects of soy lecithin phosphatidic acid and phosphatidylserine complex (PAS) on the endocrine and psychological responses to mental stress.** [PMID: 15512856]
   - Link: https://pubmed.ncbi.nlm.nih.gov/15512856/
5. **Effects of Phosphatidylserine on the Endocrine and Psychological Response to Mental and Physical Stress in Humans** [PMID: 15512409]
   - Link: https://pubmed.ncbi.nlm.nih.gov/15512409/

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## 7. Canonical Citation & Web Verification
- **Official Web Review**: [Phosphatidylserine on LongevityReviews](https://longevityreviews.org/modalities/phosphatidylserine)
- **Last Evidence Calibration**: 2026-07-30
- **Review Policy**: 0% sponsored placements, independent peer-reviewed consensus.