Once systemic, it operates via a highly powerful, synergistic dual-action mechanism to suppress central nervous system hyperactivity. The magnesium ion acts as a critical enzymatic cofactor for ATP production and serves as a natural voltage-gated antagonist at the N-methyl-D-aspartate (NMDA) receptor32. By physically blocking the receptor channel, it actively prevents the excitatory neurotransmitter glutamate from causing excessive calcium influx, effectively halting neuro-excitotoxicity and instantly shutting down "racing thoughts"32. Simultaneously, the magnesium heavily facilitates the binding of GABA to its receptors, directly supporting endogenous melatonin regulation and restoring HPA-axis balance32. Meanwhile, the two cleaved glycine molecules act entirely independently as inhibitory neurotransmitters in the brainstem, driving massive peripheral vasodilation and forcing a rapid drop in core body temperature59. Together, this synergistic compound forces a "bottom-up" physical relaxation of somatic muscle tissue while initiating "top-down" neurological sedation, profoundly improving both sleep latency and deep slow-wave sleep architecture32.