The 8 Canonical Longevity Vectors

Targeted Biological Hubs of Human Healthspan

Every clinical intervention and protocol stack on LongevityReviews is mapped across 8 canonical physiological vectors. Explore ranked evidence ledgers, landmark human RCTs, and clinical biomarker targets for each biological domain.

132 Evaluated Interventions

Heart Health & Endothelial Function

Cardiovascular output, endothelial elasticity, VO2 max & arterial compliance

Target Clinical Biomarkers:

VO2 MaxApoBLp(a)CAC ScoreEndothelial FMDResting Heart Rate

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145 Evaluated Interventions

Brain Longevity & Neuroprotection

Hippocampal plasticity, neurogenesis, synaptic density & glymphatic clearance

Target Clinical Biomarkers:

BDNFDeep NREM SleepGlymphatic FlowProcessing SpeedSerum Neurofilament Light (NfL)

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139 Evaluated Interventions

Metabolic Flexibility & Glycemic Control

Insulin sensitivity, substrate switching, mitochondrial uncoupling & visceral fat reduction

Target Clinical Biomarkers:

HOMA-IRFasting InsulinHbA1cPostprandial Glycemic AreaTriglyceride/HDL Ratio

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126 Evaluated Interventions

Cancer Defense & DNA Repair

Immunosurveillance, genomic stability, PARP activation & senescent cell purge

Target Clinical Biomarkers:

NK Cell CytotoxicityCirculating Tumor DNA (ctDNA)8-OHdGgamma-H2AX FociMCED Grail Test

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89 Evaluated Interventions

Endocrine & Anabolic Balance

Leydig cell output, free androgen index, LH/FSH axis & lean mass signaling

Target Clinical Biomarkers:

Free TestosteroneTotal TestosteroneSHBGDHEA-SIGF-1 / IGFBP-3 Ratio

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154 Evaluated Interventions

Chronic Inflammation Reduction

Suppression of sterile low-grade inflamma-aging and SASP secretome

Target Clinical Biomarkers:

hs-CRPIL-6TNF-alphaFibrinogenNeutrophil-to-Lymphocyte Ratio (NLR)

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92 Evaluated Interventions

Bone Density & Connective Matrix

Osteoblast mechanotransduction, trabecular architecture & collagen synthesis

Target Clinical Biomarkers:

DEXA Lumbar & Femoral T-ScoreSerum P1NPCTX Bone ResorptionTendon Stiffness

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165 Evaluated Interventions

Cellular Longevity & Autophagy

Mitophagy velocity, sirtuin/AMPK activation, stem cell renewal & telomere maintenance

Target Clinical Biomarkers:

DunedinPACE Epigenetic ClockGrimAge v2 AccelerationIntracellular NAD+ PoolLC3-II Autophagy Flux

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